The Last Generation (2008-2009)
Written by Andrew Steven Harris
Illustrated by Gordon Purcell
Set in an alternate timeline, the Federation is in ruins after James T. Kirk failed during the events of Star Trek VI: The Undiscovered Country and now Earth is under Klingon rule. Data knows things are amiss, Worf is a warlord and this book is chaotic fun.
Star Trek: Year Four (2007-2008)
Written by David Tischman
Illustrated by Steve Conley, Gordon Purcell & Rob, and Joe Sharp
Star Trek: The Original Series saw its characters launched as part of a five-year mission, and this is year four of that mission.
The Worst of Both Worlds (1993)
A what-if that features Jean-Luc Picard having never been rescued from the Borg and the results are not good.